This awareness is a great gift - that you acknowledge it and are offering to help him. You might also consider some type of therapy or group support for you - a confidential, safe place to share your struggles. Yes - men (and women, too, I suspect) do tend to do a bit of "life review" around mid-life (at or near 40 or so) and start examining choices - this can lead to all sorts of reckoning. Be there for him, be strong, and find some support for yourself.